
Hong JB, Jing QQ, Yao LS (2013) The protein amide H-1(N) chemical shift temperature coefficient reflects thermal expansion of the N-H center dot center dot center dot O=C hydrogen bond.Morales P, Jimenez MA (2019) Design and structural characterisation of monomeric water-soluble alpha-helix and beta-hairpin peptides: State-of-the-art.Rao T, Ruiz-Gomez G, Hill TA et al (2013) Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1.Gooding EA, Sharma S, Petty SA et al (2013) pH-dependent helix folding dynamics of poly-glutamic acid.Hoang HN, Abbenante G, Hill TA et al (2012) Folding pentapeptides into left and right handed alpha helices.Rogers DM, Jasim SB, Dyer NT et al (2019) Electronic circular dichroism spectroscopy of proteins.Ezerski JC, Zhang P, Jennings NC et al (2020) Molecular dynamics ensemble refinement of intrinsically disordered peptides according to deconvoluted spectra from circular dichroism.Hamrang Z, Rattray NJW, Pluen A (2013) Proteins behaving badly: emerging technologies in profiling biopharmaceutical aggregation.Schiavone NM, Pirrone GF, Guetschow ED et al (2019) Combination of circular dichroism spectroscopy and size-exclusion chromatography coupled with HDX-MS for studying global conformational structures of peptides in solution.Wang DY, Yu MY, Liu N et al (2019) A sulfonium tethered peptide ligand rapidly and selectively modifies protein cysteine in vicinity.Li Y, Lian CS, Hou ZF et al (2020) Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation.Jackson DY, King DS, Chmielewski J et al (1991) General-approach to the synthesis of short alpha-helical peptides.Lau YH, De Andrade P, Wu YT et al (2015) Peptide stapling techniques based on different macrocyclisation chemistries.Kawamoto SA, Coleska A, Ran X et al (2012) Design of triazole-stapled BCL9 alpha-helical peptides to target the beta-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction.Zhao H, Liu QS, Geng H et al (2016) Crosslinked aspartic acids as helix-nucleating templates.Tu L, Wang D, Li Z (2019) Design and synthetic strategies for helical peptides.Edwards TA, Wilson AJ (2011) Helix-mediated protein-protein interactions as targets for intervention using foldamers.Walensky LD, Kung AL, Escher I et al (2004) Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.Walensky LD, Bird GH (2014) Hydrocarbon-stapled peptides: principles, practice, and progress.Hu K, Geng H, Zhang Q et al (2016) An in-tether chiral center modulates the helicity, cell permeability, and target binding affinity of a peptide.Tsomaia N (2015) Peptide therapeutics: targeting the undruggable space.Vlieghe P, Lisowski V, Martinez J et al (2010) Synthetic therapeutic peptides: science and market.Ali AM, Atmaj J, Van Oosterwijk N et al (2019) Stapled peptides inhibitors: a new window for target drug discovery.Wojcik P, Berlicki L (2016) Peptide-based inhibitors of protein-protein interactions.


Okona first debuted on The Next Generation and was played by Billy Campbell, and the character was last seen on Lower Decks in a minor role but will return to Prodigy as a recurring character.

Stapled helix series#
Another way they may be trying to lure older fans into the series is with the series debut of another classic Star Trek character Thadiun Okona. It’s finding ways to appeal to both old and new fans alike. The show also brought in Spock, Odo, Uhura, and others for a special cameo as holodeck characters.

The show has already used Kathryn Janeway (Kate Mulgrew) and Chakotay (Robert Beltran) to help attract fans of a different ages into the series, but that wasn’t all. It isn’t just trying to open up doors for new fans, however, as the series also does a great job of attracting older fans back with their use of classic characters. Star Trek: Prodigy is a great series that does a wonderful job of creating an entry point for new fans to get into the series. Star Trek: Prodigyg is returning on October 27 with a classic character in tow.
